SCHEMBL25367430

SCHEMBL25367430

C=C(C=O)c1ccc2c(c1)C(C)(C)CC2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 15/20 0.42
▸ RARB P10826 11/20 0.42
▸ RARG P13631 11/20 0.42
▸ RARA P10276 9/20 0.42
▸ RXRB P28702 8/20 0.42
▸ RXRG P48443 7/20 0.42
▸ CYP26A1 O43174 2/20 0.39
▸ RECQL P46063 2/20 0.39
▸ BLM P54132 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ GMNN O75496 1/20 0.39
▸ USP2 O75604 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25369126 0.89 RXRA (0.41) RXRARARBRARGRARARXRB
SCHEMBL18741106 0.78 RXRA (0.46) RXRARARBRARGRARARXRB
SCHEMBL18740981 0.77 NPC1 (0.50) RXRARARBRARGRARARXRB
SCHEMBL31084998 0.77 NPC1 (0.50) RXRARARBRARGRARARXRB
SCHEMBL25367506 0.76 ESR2 (0.41) RXRARARBRARGRARARXRB
SCHEMBL25367040 0.75 RXRA (0.33) RXRARARBRARGRARARXRB
SCHEMBL6554255 0.73 CYP3A4 (0.45) RXRARARBRARGRARARXRB
SCHEMBL12633189 0.72 RXRA (0.33) RXRARARBRARGRARARXRB
SCHEMBL18741109 0.71 RARB (0.40) RXRARARBRARGRARACYP26A1
SCHEMBL30298339 0.71 RARB (0.40) RXRARARBRARGRARACYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583809-B2 Process for preparing indene acryladehyde derivatives FIRMENICH SA (CH) 2026-03-24 — — US disclosed
EP-4149913-B1 PROCESS FOR PREPARING INDENE ACRYLADEHYDE DERIVATIVES FIRMENICH & CIE (CH) 2024-07-17 — — EP disclosed
US-20230271911-A1 PROCESS FOR PREPARING INDENE ACRYLADEHYDE DERIVATIVES FIRMENICH SA (CH) 2023-08-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583809-B2 Process for preparing indene acryladehyde derivatives CBR1, CYP2E1, CYP2C8 RXRA 476/4885RARB 1330/4885RARG 1373/4885
US-20230271911-A1 PROCESS FOR PREPARING INDENE ACRYLADEHYDE DERIVATIVES HPD, IMPDH1, IMPDH2 RXRA 4158/4885RARB 4322/4885RARG 4562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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