SCHEMBL25369126

SCHEMBL25369126

C=C(C=O)c1ccc2c(c1)CCC2(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 12/20 0.41
▸ RARB P10826 11/20 0.41
▸ RARG P13631 10/20 0.41
▸ RARA P10276 8/20 0.41
▸ RXRB P28702 7/20 0.41
▸ RXRG P48443 6/20 0.41
▸ KDM4E B2RXH2 3/20 0.39
▸ BLM P54132 3/20 0.39
▸ MAPT P10636 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ POLB P06746 2/20 0.39
▸ CYP2C19 P33261 2/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ GRM1 Q13255 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ CYP26A1 O43174 2/20 0.38
▸ RECQL P46063 2/20 0.38
▸ NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25367430 0.89 RXRA (0.42) RXRARARBRARGRARARXRB
SCHEMBL25367506 0.83 ESR2 (0.41) RXRARARBRARGRARARXRB
SCHEMBL28963433 0.79 KDM4E (0.42) RXRARARBRARGRARARXRB
SCHEMBL12516220 0.78 MAPT (0.53) RXRARARBRARGRARARXRB
SCHEMBL25367710 0.76 RARA (0.33) RXRARARBRARGRARARXRB
SCHEMBL14817238 0.74 KDM1A (0.44) RXRARARBRARGRARARXRB
SCHEMBL12517014 0.73 KDM1A (0.43) RXRARARBRARGRARARXRB
SCHEMBL2224448 0.73 GNG2 (0.45) RXRARARBRARGRXRBRXRG
SCHEMBL5176543 0.72 ALDH1A1 (0.41) RXRARARBRARGRARAKDM4E
SCHEMBL30298330 0.72 ALDH1A1 (0.41) RXRARARBRARGRARAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583809-B2 Process for preparing indene acryladehyde derivatives FIRMENICH SA (CH) 2026-03-24 — — US disclosed
EP-4149913-B1 PROCESS FOR PREPARING INDENE ACRYLADEHYDE DERIVATIVES FIRMENICH & CIE (CH) 2024-07-17 — — EP disclosed
US-20230271911-A1 PROCESS FOR PREPARING INDENE ACRYLADEHYDE DERIVATIVES FIRMENICH SA (CH) 2023-08-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583809-B2 Process for preparing indene acryladehyde derivatives CBR1, CYP2E1, CYP2C8 RXRA 476/4885RARB 1330/4885RARG 1373/4885
US-20230271911-A1 PROCESS FOR PREPARING INDENE ACRYLADEHYDE DERIVATIVES HPD, IMPDH1, IMPDH2 RXRA 4158/4885RARB 4322/4885RARG 4562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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