Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542029 | 0.80 | — | — | |
| SCHEMBL3746243 | 0.79 | ALDH1A1 (0.36) | SMN1; SMN2LMNAALDH1A1HSD17B10GPR119 | |
| SCHEMBL24580648 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL1815035 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL5411525 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL8198244 | 0.75 | TSHR (0.44) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL3604706 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL1153474 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL1810872 | 0.75 | SMN1; SMN2 (0.36) | SMN1; SMN2ATMLMNAALDH1A1HSD17B10 | |
| SCHEMBL22898114 | 0.74 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1POLBMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185563-B1 | OXASPIROCYCLIC SPIRO-SUBSTITUTED TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2015-08-19 | — | — | EP | disclosed |
| US-8859466-B2 | Oxaspirocyclic spiro-substituted tetramic acid and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8859466-B2 | Oxaspirocyclic spiro-substituted tetramic acid and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8859466-B2 | Oxaspirocyclic spiro-substituted tetramic acid and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| US-20110263424-A1 | Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263424-A1 | Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263424-A1 | Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-10-27 | — | — | US | disclosed |
| WO-2009015801-A1 | OXASPIROCYCLIC SPIRO-SUBSTITUTED TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-02-05 | — | — | WO | disclosed |
| EP-2020413-A1 | Oxaspirocyclical spiro-substituted tetram and tetron acid derivatives | Bayer CropScience AG (DE) | 2009-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263424-A1 | Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives | TBCA, POF1B, DDT | SMN1; SMN2 3634/4885ATM 3803/4885LMNA 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.