Sugi Predict

Sugi Predict / Compounds / Bromide

Bromide

Bromide

SCHEMBL25370643

Cc1cccc(C(F)(F)F)c1C[Zn+].[Br-]

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 2/20 0.37
▸ RORC P51449 1/20 0.36
▸ SCN8A Q9UQD0 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ GABRA1 P14867 1/20 0.34
▸ GABRB2 P47870 1/20 0.34
▸ TRPA1 O75762 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ HSD11B1 P28845 2/20 0.33
▸ RAPGEF4 Q8WZA2 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13856265 0.80 TAAR1 (0.39) TAAR1RORCSCN8ASMN1; SMN2GABRA1
Bromide SCHEMBL25371462 0.79 CYP2A6 (0.41) TAAR1TRPA1ALDH1A1ATMTDP1
SCHEMBL25372761 0.78 TAAR1 (0.38) TAAR1RORCSCN8ASMN1; SMN2GABRA1
SCHEMBL30723720 0.78 RORC (0.40) TAAR1RORCSCN8ASMN1; SMN2GABRA1
Bromide SCHEMBL25372266 0.78 SLC6A2 (0.40) TAAR1SMN1; SMN2TRPA1HSD11B1CYP3A4
SCHEMBL10026821 0.77 GABRA1 (0.38) TAAR1RORCSCN8ASMN1; SMN2GABRA1
Bromide SCHEMBL25372781 0.77 HSD11B1 (0.38) TAAR1RORCGAAHSD11B1P2RX7
Bromide SCHEMBL25371177 0.77 MAPT (0.40) SMN1; SMN2KDM4EATMTDP1MEN1
SCHEMBL23841329 0.76 P2RX7 (0.39) TAAR1RORCSCN8ASMN1; SMN2GABRA1
SCHEMBL20348821 0.74 SMN1; SMN2 (0.37) TAAR1RORCSCN8ASMN1; SMN2GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240002344-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION FIBROGEN, INC. 2024-01-04 — — US disclosed
EP-4204400-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION Fibrogen, Inc. (US) 2023-07-05 — — EP disclosed
CN-116348450-A Compounds, compositions and methods for histone lysine demethylase inhibition 菲布罗根有限公司 2023-06-27 — — CN disclosed
WO-2022047230-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION FIBROGEN, INC. (US) 2022-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240002344-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION KDM5C, KDM5B, KDM5A TAAR1 4600/4885RORC 716/4885SCN8A 3236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.