Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30544011 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRMAPK10KMT2APOLB | |
| SCHEMBL25432217 | 0.86 | RAB9A (0.50) | SMN1; SMN2KMT2ARAB9ANPC1MAPT | |
| SCHEMBL30543921 | 0.86 | RAB9A (0.50) | SMN1; SMN2KMT2ARAB9ANPC1MAPT | |
| SCHEMBL30544024 | 0.81 | CSNK2A1 (0.47) | KMT2AMEN1ROCK1 | |
| SCHEMBL25432990 | 0.81 | CSNK2A1 (0.47) | KMT2AMEN1ROCK1 | |
| SCHEMBL25368280 | 0.78 | DHX9 (0.53) | SMN1; SMN2KMT2APOLBRAB9AMAPT | |
| SCHEMBL30543946 | 0.78 | DHX9 (0.53) | SMN1; SMN2KMT2APOLBRAB9AMAPT | |
| SCHEMBL25433357 | 0.78 | NFATC1 (0.54) | KMT2ARAB9ANPC1MAPTMEN1 | |
| SCHEMBL25368472 | 0.76 | LMNA (0.48) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL25367979 | 0.76 | ALDH1A1 (0.46) | TSHRMAPTROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | claimed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |