Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.65 |
| ▸ | DRD3 | P35462 | 8/20 | 0.65 |
| ▸ | DRD4 | P21917 | 6/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | CNR1 | P21554 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25370740 | 1.00 | DRD2 (0.65) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL15323709 | 0.84 | DRD2 (0.76) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL50425 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL30200958 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL7333060 | 0.79 | DRD2 (0.77) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL1088585 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL9405994 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL29354493 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL2597402 | 0.78 | DRD2 (0.98) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL2597403 | 0.78 | DRD2 (0.98) | DRD2DRD3DRD4HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230391744-A1 | TETRAHYDRONAPHTHALENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. (CN) | 2023-12-07 | — | — | US | disclosed |
| EP-4238966-A1 | TETRAHYDRONAPHTHALENE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Guangzhou Henovcom Bioscience Co. Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| CN-114478476-B | Tetrahydronaphthalene compounds, pharmaceutical composition and application thereof | 广州市恒诺康医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114478476-A | Tetrahydronaphthalenes compounds, pharmaceutical compositions and uses thereof | 广州市恒诺康医药科技有限公司 | 2022-05-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391744-A1 | TETRAHYDRONAPHTHALENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | CYP11B2, HTT, REN | DRD2 769/4885DRD3 222/4885DRD4 1027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.