Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.76 |
| ▸ | DRD3 | P35462 | 9/20 | 0.76 |
| ▸ | DRD4 | P21917 | 5/20 | 0.76 |
| ▸ | HTR1A | P08908 | 2/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | DRD1 | P21728 | 1/20 | 0.72 |
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | HRH1 | P35367 | 1/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9586560 | 0.87 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL1987776 | 0.85 | DRD2 (0.86) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL1682779 | 0.85 | DRD2 (0.86) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL29992240 | 0.85 | DRD2 (0.86) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL31556291 | 0.85 | DRD2 (0.86) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL25370930 | 0.84 | DRD2 (0.65) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL9405994 | 0.84 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| Rotigotine SCHEMBL1088585 | 0.84 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL2021960 | 0.84 | HTR1A (0.84) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL2021032 | 0.84 | HTR1A (0.84) | DRD2DRD3DRD4HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014242-A1 | COMPOSITIONS COMPRISING BIOREVERSIBLE DERIVATIVES OF HYDROXY N-SUBSTITUTED-2-AMINOTETRALINS, DOSAGE FORMS, AND RELATED METHODS | SPRIASO LLC (US) | 2016-01-28 | — | — | WO | claimed |
| WO-2016014242-A1 | COMPOSITIONS COMPRISING BIOREVERSIBLE DERIVATIVES OF HYDROXY N-SUBSTITUTED-2-AMINOTETRALINS, DOSAGE FORMS, AND RELATED METHODS | SPRIASO LLC (US) | 2016-01-28 | — | — | WO | disclosed |
| EP-2833875-A1 | A DOPAMINE-AGONIST-CONTAINING TRANSDERMAL APPLICATION SYSTEM | Acino AG (DE) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150032-A1 | A DOPAMINE-AGONIST-CONTAINING TRANSDERMAL APPLICATION SYSTEM | ACINO AG (DE) | 2013-10-10 | — | — | WO | disclosed |