Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30482521 | 1.00 | TP53 (0.45) | TP53MAPTBRD4AKR1C3TEAD1 | |
| SCHEMBL30519396 | 0.77 | KIF11 (0.62) | TP53MAPTAKR1C3KIF11MEN1 | |
| SCHEMBL25977664 | 0.77 | KIF11 (0.62) | TP53MAPTAKR1C3KIF11MEN1 | |
| SCHEMBL16481432 | 0.76 | KIF11 (0.52) | TP53MAPTAKR1C3KIF11MEN1 | |
| SCHEMBL25429357 | 0.76 | TP53 (0.42) | TP53MAPTAKR1C3TEAD1YAP1 | |
| SCHEMBL30544076 | 0.75 | GPR139 (0.38) | TP53MAPTAKR1C3TEAD1YAP1 | |
| SCHEMBL25340693 | 0.75 | GPR139 (0.38) | TP53MAPTAKR1C3TEAD1YAP1 | |
| SCHEMBL25430365 | 0.74 | PTGS2 (0.50) | TP53MAPTKIF11MEN1HTT | |
| SCHEMBL25431454 | 0.74 | TP53 (0.46) | TP53MAPTAKR1C3KIF11MEN1 | |
| SCHEMBL25429614 | 0.74 | AKR1C3 (0.56) | TP53MAPTAKR1C3MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146512-A1 | COMPOUNDS AND METHODS OF USE THEREOF | VIVACE THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146512-A1 | COMPOUNDS AND METHODS OF USE THEREOF | VIVACE THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |