Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31018193 | 1.00 | HTT (0.52) | HTTSMN1; SMN2NAMPTLMNAALDH1A1 | |
| SCHEMBL617600 | 0.90 | HTT (0.54) | HTTSMN1; SMN2HDAC6HPGDSUCNR1 | |
| SCHEMBL10278163 | 0.87 | EGLN1 (0.57) | HTTSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL618734 | 0.86 | EGLN1 (0.60) | HTTSMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL616709 | 0.86 | SMN1; SMN2 (0.54) | HTTSMN1; SMN2LMNAMAPTHDAC6 | |
| SCHEMBL619017 | 0.86 | HTT (0.69) | HTTSMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL254150 | 0.86 | MAPK1 (0.55) | HTTSMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL619739 | 0.86 | HTT (0.47) | HTTSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL619639 | 0.85 | HTT (0.56) | HTTSMN1; SMN2LMNAALDH1A1RAB9A | |
| SCHEMBL616686 | 0.85 | SMN1; SMN2 (0.41) | HTTSMN1; SMN2LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-B1 | NAPHTHYRIDINE DERIVATIVES HAVING BRONCHODILATING ACTIVITY | RESPIRATORIUS AB (SE) | 2013-07-24 | — | — | EP | claimed |
| US-8415333-B2 | Bronchodilating diazaheteroaryls | RESPIRATORIOUS AB (SE) | 2013-04-09 | — | — | US | claimed |
| US-20120040942-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2012-02-16 | — | — | US | claimed |
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | claimed |
| CN-112437771-B | Bronchodilating heteroatom-linked amides | 阿凯德制药公司 | 2024-06-18 | — | — | CN | disclosed |
| US-11680054-B2 | Bronchodilating hetero-linked amides | ARCEDE PHARMA AB (SE) | 2023-06-20 | — | — | US | disclosed |
| EP-3818055-B1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | RESPIRATORIUS AB PUBL (SE) | 2022-02-16 | — | — | EP | disclosed |
| US-20210139455-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | ARCEDE PHARMA AB (SE) | 2021-05-13 | — | — | US | disclosed |
| EP-3818055-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | Respiratorius AB (Publ) (SE) | 2021-05-12 | — | — | EP | disclosed |
| CN-112437771-A | Novel bronchodilator heteroatom-linked amides | 瑞思拜尔锐特略斯股份公司 | 2021-03-02 | — | — | CN | disclosed |
| WO-2020009653-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | RESPIRATORIUS AB (PUBL) (SE) | 2020-01-09 | — | — | WO | disclosed |
| EP-2401275-B1 | NAPHTHYRIDINE DERIVATIVES HAVING BRONCHODILATING ACTIVITY | RESPIRATORIUS AB (SE) | 2013-07-24 | — | — | EP | disclosed |
| US-8415333-B2 | Bronchodilating diazaheteroaryls | RESPIRATORIOUS AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-8415333-B2 | Bronchodilating diazaheteroaryls | RESPIRATORIOUS AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-8415333-B2 | Bronchodilating diazaheteroaryls | RESPIRATORIOUS AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-20120040942-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2012-02-16 | — | — | US | disclosed |
| US-20120040942-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2012-02-16 | — | — | US | disclosed |
| US-20120040942-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2012-02-16 | — | — | US | disclosed |
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097410-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11680054-B2 | Bronchodilating hetero-linked amides | PTGIS, PTGIR, ADRB2 | HTT 3525/4885SMN1; SMN2 4854/4885NAMPT 2321/4885 |
| US-20120040942-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | CHRM3, ADRB1, ADRB3 | HTT 4219/4885SMN1; SMN2 4137/4885NAMPT 2850/4885 |
| US-20210139455-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | ADRB2, ADRB1, PTGIS | HTT 3683/4885SMN1; SMN2 4870/4885NAMPT 2513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.