SCHEMBL25396644

SCHEMBL25396644

Nc1ccn([C@@]2(F)C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1

nearest known ligand 0.61

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.51
POLB P06746 1/20 0.47
P2RY2 P41231 8/20 0.46
P2RY6 Q15077 7/20 0.46
P2RY4 P51582 4/20 0.46
POLA1 P09884 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31448322 0.91 POLB (0.46) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL6141746 0.88 POLG (0.51) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL585724 0.87 POLG (0.51) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL17215886 0.87 POLG (0.51) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL6038233 0.86 POLG (0.50) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL597307 0.85 POLG (0.49) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL10900419 0.85 POLG (0.49) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL27451032 0.85 POLG (0.49) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL5708922 0.84 POLG (0.48) POLGPOLBP2RY2P2RY6P2RY4
SCHEMBL29978240 0.84 POLG (0.47) POLGPOLBP2RY2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638362-B Dry powder formulations of messenger RNA 川斯勒佰尔公司 2025-06-13 CN disclosed
CN-119451988-B Anti-B7-H3 antibodies and uses thereof 乐普创一生物科技(上海)有限公司 2025-06-03 CN disclosed
CN-119930823-A Anti-CCR 8 antibodies and uses thereof 乐普创一生物科技(上海)有限公司 2025-05-06 CN disclosed
CN-119735678-A Tumor antigen dependent CD40 agonist single domain antibodies 乐普创一生物科技(上海)有限公司 2025-04-01 CN disclosed
CN-119662655-A Application of RNA molecule and composition thereof in tumor immunotherapy 武汉厚先生物医药有限公司 2025-03-21 CN disclosed
CN-112384523-B Ribose cationic lipids 川斯勒佰尔公司 2025-03-14 CN disclosed
CN-119462954-A 5T4/CD40 bispecific antibodies 乐普创一生物科技(上海)有限公司 2025-02-18 CN disclosed
CN-119451988-A Anti-B7-H3 antibodies and uses thereof 乐普创一生物科技(上海)有限公司 2025-02-14 CN disclosed
CN-119110732-A Gene editing for improving joint function 奥泽生物疗法公司 2024-12-10 CN disclosed
CN-112533909-B Vitamin cationic lipids 川斯勒佰尔公司 2024-11-15 CN disclosed
CN-115916158-A Lipid nanoparticle formulations for mRNA delivery 翻译生物公司 2023-04-04 CN disclosed
EP-4110296-A1 IMPROVED PROCESSES OF PREPARING MRNA-LOADED LIPID NANOPARTICLES Translate Bio, Inc. (US) 2023-01-04 EP disclosed
CN-115515559-A Rectal delivery of messenger RNA 翻译生物公司 2022-12-23 CN disclosed
CN-115461042-A Improved method for preparing MRNA-loaded lipid nanoparticles 翻译生物公司 2022-12-09 CN disclosed
CN-115443338-A Methods and compositions for messenger RNA purification 翻译生物公司 2022-12-06 CN disclosed
CN-115427021-A Improved method for preparing MRNA-loaded lipid nanoparticles 翻译生物公司 2022-12-02 CN disclosed
CN-106795142-B Stereochemically enriched compositions for delivery of nucleic acids 川斯勒佰尔公司 2022-11-04 CN disclosed
CN-109072223-B Multimeric coding nucleic acids and uses thereof 川斯勒佰尔公司 2022-10-21 CN disclosed
WO-2022081544-A1 IMPROVED PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES TRANSLATE BIO, INC. (US) 2022-04-21 WO disclosed
WO-2022081548-A1 IMPROVED PROCESS OF PREPARING ICE-BASED LIPID NANOPARTICLES TRANSLATE BIO, INC. (US) 2022-04-21 WO disclosed