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Sugi Predict / Compounds / SCHEMBL25397376

SCHEMBL25397376

SCHEMBL25397376

O=C(O)COc1cc(Cl)c(Cc2ccc(O)c(-c3cncc(F)c3)c2)c(Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 16/20 0.57
▸ THRA P10827 14/20 0.57
▸ LDHA P00338 1/20 0.40
▸ FFAR1 O14842 1/20 0.37
▸ ABL1 P00519 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30574231 1.00 THRB (0.57) THRBTHRALDHAFFAR1ABL1
SCHEMBL31350370 0.91 THRA (0.46) THRBTHRAABL1
SCHEMBL31350420 0.89 THRA (0.47) THRBTHRAABL1
SCHEMBL25398440 0.88 THRB (0.62) THRBTHRALDHAFFAR1
SCHEMBL25401057 0.87 THRB (0.61) THRBTHRA
SCHEMBL25398425 0.86 THRB (0.62) THRBTHRAFFAR1
SCHEMBL30574229 0.85 THRA (0.59) THRBTHRA
SCHEMBL25396983 0.85 THRA (0.59) THRBTHRAFFAR1
SCHEMBL25399834 0.85 THRA (0.59) THRBTHRA
SCHEMBL25397334 0.84 THRB (0.62) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023177667-A1 THYROID HORMONE RECEPTOR AGONISTS BRII BIOSCIENCES, INC. (US) 2023-09-21 — — WO claimed
WO-2023177667-A1 THYROID HORMONE RECEPTOR AGONISTS BRII BIOSCIENCES, INC. (US) 2023-09-21 — — WO disclosed
WO-2023177667-A1 THYROID HORMONE RECEPTOR AGONISTS BRII BIOSCIENCES, INC. (US) 2023-09-21 — — WO disclosed