Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.65 |
| ▸ | THRA | P10827 | 13/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23003630 | 0.92 | THRA (0.66) | THRBTHRAPTGDR2 | |
| SCHEMBL30574232 | 0.92 | THRA (0.66) | THRBTHRAPTGDR2 | |
| SCHEMBL25398425 | 0.91 | THRB (0.62) | THRBTHRAMAP4K4 | |
| SCHEMBL31350392 | 0.89 | THRA (0.52) | THRBTHRAMAP4K4 | |
| SCHEMBL25400128 | 0.89 | THRB (0.60) | THRBTHRA | |
| SCHEMBL25398704 | 0.89 | THRB (0.60) | THRBTHRA | |
| SCHEMBL25397334 | 0.88 | THRB (0.62) | THRBTHRA | |
| SCHEMBL23003650 | 0.87 | THRA (0.61) | THRBTHRAPTGDR2 | |
| SCHEMBL30574240 | 0.87 | THRA (0.61) | THRBTHRAPTGDR2 | |
| SCHEMBL25400891 | 0.86 | THRB (0.60) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177667-A1 | THYROID HORMONE RECEPTOR AGONISTS | BRII BIOSCIENCES, INC. (US) | 2023-09-21 | — | — | WO | claimed |
| WO-2023177667-A1 | THYROID HORMONE RECEPTOR AGONISTS | BRII BIOSCIENCES, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177667-A1 | THYROID HORMONE RECEPTOR AGONISTS | BRII BIOSCIENCES, INC. (US) | 2023-09-21 | — | — | WO | disclosed |