Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15042204 | 0.84 | CYP1A2 (0.50) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL17047076 | 0.84 | CYP1A2 (0.50) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL6954058 | 0.83 | CYP1A2 (0.49) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7228578 | 0.83 | CYP1A2 (0.49) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL28362314 | 0.82 | CYP2C19 (0.50) | CYP1A2CYP3A4 | |
| SCHEMBL28773067 | 0.81 | ALDH1A1 (0.45) | LMNACYP1A2CYP3A4TBXAS1NAPRT | |
| SCHEMBL5497374 | 0.77 | TBXAS1 (0.49) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL6979883 | 0.76 | CYP1A2 (0.54) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL6979885 | 0.76 | CYP1A2 (0.54) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL6037641 | 0.76 | CYP1A2 (0.54) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114729006-A | Cyclic peptide compounds having Kras inhibitory activity | 中外制药株式会社 | 2022-07-08 | — | — | CN | disclosed |
| EP-2611788-B1 | NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE | UNIV FLORIDA (US) | 2017-04-12 | — | — | EP | disclosed |
| US-9440948-B2 | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440948-B2 | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20130157995-A1 | NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-06-20 | — | — | US | disclosed |
| US-20130157995-A1 | NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-06-20 | — | — | US | disclosed |
| WO-2012031220-A2 | NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130157995-A1 | NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE | CHRNG, CHRNB1, CHRNB2 | LMNA 2464/4885CYP1A2 341/4885CYP3A4 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.