Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.66 |
| ▸ | MEN1 | O00255 | 10/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.66 |
| ▸ | HTT | P42858 | 7/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | GAA | P10253 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.48 |
| ▸ | POLB | P06746 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 4/20 | 0.47 |
| ▸ | MPI | P34949 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15242456 | 0.91 | MAPT (0.55) | MAPTMEN1KMT2AHTTTDP1 | |
| SCHEMBL1132108 | 0.59 | GAA (0.52) | MAPTMEN1KMT2AHTTTDP1 | |
| SCHEMBL1132110 | 0.59 | GAA (0.52) | MAPTMEN1KMT2AHTTTDP1 | |
| SCHEMBL12700773 | 0.56 | CASP6 (0.53) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL30714872 | 0.55 | MAPT (0.69) | MAPTMEN1KMT2AHTTKDM4E | |
| SCHEMBL6068094 | 0.55 | ALOX5 (0.47) | MAPTMEN1KMT2AHTTKDM4E | |
| SCHEMBL1132158 | 0.55 | MAPT (0.63) | MAPTMEN1KMT2AHTTTDP1 | |
| SCHEMBL1132128 | 0.55 | MAPT (0.63) | MAPTMEN1KMT2AHTTTDP1 | |
| SCHEMBL10049961 | 0.54 | SMN1; SMN2 (0.65) | MAPTMEN1KMT2AHTTTDP1 | |
| SCHEMBL28202407 | 0.54 | PIK3R1 (0.56) | MAPTMEN1KMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676763-B2 | Method of treating Ebola | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160024066-A1 | Small Molecule Inhibitors of Ebola and Lassa Fever Viruses and Methods of Use | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2016-01-28 | — | — | US | disclosed |
| US-9193705-B2 | Small molecule inhibitors of ebola and lassa fever viruses and methods of use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-11-24 | — | — | US | disclosed |
| US-20130231332-A1 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-09-05 | — | — | US | disclosed |
| WO-2012031090-A2 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024066-A1 | Small Molecule Inhibitors of Ebola and Lassa Fever Viruses and Methods of Use | LASP1, LAS1L, HSP90B1 | MAPT 1825/4885MEN1 3233/4885KMT2A 4278/4885 |
| US-20130231332-A1 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | LASP1, LAS1L, HSP90B1 | MAPT 1825/4885MEN1 3233/4885KMT2A 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.