Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propoxyphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | HRH2 | P25021 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propoxyphene SCHEMBL6279254 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL21775586 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL25405 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Levopropoxyphene SCHEMBL158770 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL16322146 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL23779946 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8675564 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8717606 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL41779 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL5500364 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 23664 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-12529704-B2 | Methods for objective assessment of stress, early detection of risk for stress disorders, matching individuals with treatments, monitoring response to treatment, and new methods of use for drugs | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2026-01-20 | — | — | US | claimed |
| US-20260007719-A1 | COMPOSITION FOR INTERMITTENT DOSING OF CALCINEURIN INHIBITORS | KLEE TREVOR (US) | 2026-01-08 | — | — | US | claimed |
| EP-4100010-B1 | NITROXIDE COMPOUNDS FOR USE IN THE TREATMENT OF OPIOID-INDUCED RESPIRATORY DEPRESSION (OIRD) | UNIV CASE WESTERN RESERVE (US) | 2026-01-07 | — | — | EP | claimed |
| WO-2025264260-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP TECHNOLOGIES, INC. (US) | 2025-12-26 | — | — | WO | claimed |
| EP-4665758-A1 | TREATMENT OF OPIOD-INDUCED PAIN | H. Lundbeck A/S (DK) | 2025-12-24 | — | — | EP | claimed |
| US-20250319074-A1 | TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME | UNIV EAST CAROLINA (US) | 2025-10-16 | — | — | US | claimed |
| US-12440489-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2025-10-14 | — | — | US | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| US-4626539-A | WITH FATTY ACID PENETRATION AID AND PROPYLENE GLYCOL | E. I. DUPONT DE NEMOURS AND COMPANY (US) | 1986-12-02 | — | — | US | claimed |
| WO-1986005684-A1 | METHOD AND COMPOSITIONS FOR CONTROLLING PAIN, DEPRESSION AND SEDATION | SEROTONIN INDUSTRIES OF CHARLESTON (US) | 1986-10-09 | — | — | WO | claimed |
| EP-0171742-A2 | Transdermal delivery of opioids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-02-19 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4486436-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | ANALGESIC ASSOCIATES (US) | 1984-12-04 | — | — | US | claimed |
| US-4464376-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | RICHARDSON-VICKS, INC. (US) | 1984-08-07 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4028467-A | Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |
| US-4025501-A | Polypeptide propoxyphene derivatives for immunoassay reagents | SYVA COMPANY (US) | 1977-05-24 | — | — | US | claimed |
| US-3936528-A | 2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID OR SALT AND CODEINE OR PROPOXYPHENE | SYNTEX CORPORATION (US) | 1976-02-03 | — | — | US | claimed |