Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propoxyphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | HRH2 | P25021 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propoxyphene SCHEMBL25406 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL6279254 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL21775586 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL25405 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Levopropoxyphene SCHEMBL158770 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL16322146 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL23779946 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8717606 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL41779 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL5500364 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828266-B2 | Topical regional neuro-affective therapy with caryophyllene | AFGIN PHARMA, LLC (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190274969-A1 | TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY WITH CARYOPHYLLENE | AFGIN PHARMA, LLC (US) | 2019-09-12 | — | — | US | disclosed |
| WO-2018148342-A1 | COMPRESSED OPEN FLOW ASSAY AND USE | ESSENLIX CORPORATION (US) | 2018-08-16 | — | — | WO | disclosed |
| US-5843445-A | Method of treating rheumatoid arthritis with type II collagen | AUTOIMMUNE, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| US-5783188-A | HAVING AT LEAST NINE AMINO ACIDS WITH A SEQUENCE OF THREE OR MORE AMINO ACIDS THAT REPEATS EITHER IDENTICALLY OR WITH CONSERVATIVE SUBSTITUTION, AND HYDROXYPROLINE IS SUBSTITUTED FOR PROLINE; SUPPRESSES AUTOIMMUNE RESPONSE | AUTOIMMUNE, INC. (US) | 1998-07-21 | — | — | US | disclosed |
| US-5720955-A | ORAL, ENTERAL OR INHALATION ADMINISTRATION | AUTOIMMUNE, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5399347-A | Method of treating rheumatoid arthritis with type II collagen | AUTOIMMUNE, INC. (US) | 1995-03-21 | — | — | US | disclosed |