Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propoxyphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.98 |
| ▸ | HRH2 | P25021 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propoxyphene SCHEMBL3425281 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL41779 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8717606 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Levopropoxyphene SCHEMBL11674402 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL9269 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL6260015 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL6263061 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL23779946 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8675564 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL16322146 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040822-A1 | READY-TO-CONSTITUTE ANALYTICAL PLATFORMS FOR CHEMICAL ANALYSES AND QUANTIFICATION | PINPOINT TESTING, LLC (US) | 2016-03-17 | — | — | WO | disclosed |
| EP-1737539-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | Warner-Lambert Company LLC (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005099823-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-27 | — | — | WO | disclosed |