Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propoxyphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | HRH2 | P25021 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propoxyphene SCHEMBL25406 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL6279254 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL21775586 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL25405 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Levopropoxyphene SCHEMBL158770 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL16322146 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8675564 | 1.00 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8717606 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL41779 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL5500364 | 0.99 | OPRM1 (1.00) | OPRM1KCNH2OPRD1MRGPRX2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000805-A1 | COMBINATION OF M-OPIOID RECEPTOR (MOR) MODULATORS FOR PREVENTING AND TREATING PAIN, SUICIDALITY AND MENTAL DISORDERS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2022-01-06 | — | — | US | disclosed |
| EP-3873447-A1 | COMBINATION OF M-OPIOID RECEPTOR (MOR) MODULATORS FOR PREVENTING AND TREATING PAIN, SUICIDALITY AND MENTAL DISORDERS | Hadasit Medical Research Services and Development Ltd. (IL) | 2021-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000805-A1 | COMBINATION OF M-OPIOID RECEPTOR (MOR) MODULATORS FOR PREVENTING AND TREATING PAIN, SUICIDALITY AND MENTAL DISORDERS | OPRM1, OPRK1, OPRL1 | OPRM1 1/4885KCNH2 1578/4885OPRD1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.