Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.72 |
| ▸ | F2 | P00734 | 1/20 | 0.72 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL160886 | 0.99 | F10 (0.71) | F10KCNH2F2KLKB1 | |
| SCHEMBL6694260 | 0.90 | KCNH2 (0.64) | F10KCNH2F2KLKB1 | |
| SCHEMBL805112 | 0.89 | RAB9A (0.58) | F10KCNH2F2 | |
| SCHEMBL890632 | 0.89 | F10 (0.71) | F10KCNH2KLKB1 | |
| SCHEMBL890676 | 0.89 | F10 (0.74) | F10KCNH2KLKB1 | |
| SCHEMBL14366426 | 0.89 | F10 (0.58) | F10KCNH2F2 | |
| SCHEMBL890791 | 0.89 | F10 (0.57) | F10KCNH2F2 | |
| SCHEMBL10177863 | 0.89 | F10 (0.57) | F10KCNH2F2 | |
| SCHEMBL6694262 | 0.88 | F10 (0.63) | F10KCNH2F2KLKB1 | |
| SCHEMBL28126263 | 0.88 | F10 (0.57) | F10KCNH2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018229796-A2 | A PROCESS FOR BETRIXABAN HYDROCHLORIDE AND BETRIXABAN MALEATE SALT | MYLAN LABORATORIES LIMITED (IN) | 2018-12-20 | — | — | WO | claimed |
| CN-105732490-A | Preparation method of betrixaban | 重庆医科大学 | 2016-07-06 | — | — | CN | claimed |
| JP-4744050-B2 | Benzamides And Related Inhibitors Of Factor Xa | — | 2011-08-10 | — | — | JP | claimed |
| US-20060020039-A1 | Benzamides and related inhibitors of factor Xa | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-26 | — | — | US | claimed |
| CN-107382897-B | Intermediate of betrixaban and preparation method and application thereof | 浙江宏元药业股份有限公司 | 2021-05-04 | — | — | CN | disclosed |
| US-20190046510-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | MILLENNIUM PHARMACEUTICALS, INC. | 2019-02-14 | — | — | US | disclosed |
| US-10179124-B2 | Benzamides and related inhibitors of factor Xa | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| US-10179124-B2 | Benzamides and related inhibitors of factor Xa | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| CN-109180573-A | A kind of preparation method of betrixaban intermediate | 珠海润都制药股份有限公司 | 2019-01-11 | — | — | CN | disclosed |
| WO-2018229796-A2 | A PROCESS FOR BETRIXABAN HYDROCHLORIDE AND BETRIXABAN MALEATE SALT | MYLAN LABORATORIES LIMITED (IN) | 2018-12-20 | — | — | WO | disclosed |
| CN-107868039-A | A kind of shellfish Qu Shaban intermediate Ns（5- chloro-2-pyridyls）- 2-（4- cyanobenzoyls）Amino ］ -5- methoxy benzamides preparation method | 中国药科大学 | 2018-04-03 | — | — | CN | disclosed |
| WO-2018042320-A1 | SALTS OF BETRIXABAN AND PROCESSES FOR PREPARATION THEREOF | DR. REDDY’S LABORATORIES LIMITED (IN) | 2018-03-08 | — | — | WO | disclosed |
| US-20030162690-A1 | Bood anticoagulant | COR THERAPEUTICS, INC. | 2003-08-28 | — | — | US | disclosed |
| EP-1259485-A2 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa | Millennium Pharmaceuticals, Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1216228-A2 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa | Millennium Pharmaceuticals, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| US-6376515-B2 | DERIVATIVES OF A 2-((4-AMIDINYLPHENYL)-CARBONYLAMINO-1,2-PHENYLENE)-CARBONYLAMINO-) PYRIDINE; POTENT AND HIGHLY SELECTIVE ANTICOAGULANTS; BIOAVAILABILITY AND/OR SOLUBILITY; PREVENTION AND TREATMENT OF THROMBOSIS AND COAGULATION | COR THERAPEUTICS, INC. | 2002-04-23 | — | — | US | disclosed |
| US-20020002183-A1 | Derivatives of a 2-((4-amidinylphenyl)-carbonylamino-1,2-phenylene)-carbonylamino-)pyridine; potent and highly selective anticoagulants; bioavailability and/or solubility; prevention and treatment of thrombosis and coagulation | MILLENNIUM PHARMACEUTICALS, INC. | 2002-01-03 | — | — | US | disclosed |
| WO-2001064642-A2 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | COR THERAPEUTICS, INC. (US) | 2001-09-07 | — | — | WO | disclosed |
| WO-2001064643-A2 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2001-09-07 | — | — | WO | disclosed |
| WO-2001019788-A2 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020039-A1 | Benzamides and related inhibitors of factor Xa | TFPI, F12, F11 | F10 10/4885KCNH2 963/4885F2 13/4885 |
| US-20190046510-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHS OF A FACTOR XA INHIBITOR | F12, F11, TFPI | F10 10/4885KCNH2 3549/4885F2 7/4885 |
| US-20020002183-A1 | Derivatives of a 2-((4-amidinylphenyl)-carbonylamino-1,2-phenylene)-carbonylamino-)pyridine; potent and highly selective anticoagulants; bioavailability and/or solubility; prevention and treatment of thrombosis and coagulation | F2, F12, PLAT | F10 14/4885KCNH2 1087/4885F2 1/4885 |
| US-10179124-B2 | Benzamides and related inhibitors of factor Xa | TFPI, F12, TFPI2 | F10 13/4885KCNH2 1032/4885F2 5/4885 |
| US-20030162690-A1 | Bood anticoagulant | F2, SERPINC1, HABP2 | F10 18/4885KCNH2 593/4885F2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.