Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 10/20 | 0.45 |
| ▸ | JAK1 | P23458 | 7/20 | 0.45 |
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30373746 | 1.00 | FEN1 (0.50) | FEN1JAK3JAK1JAK2IKBKE | |
| SCHEMBL22838439 | 0.76 | ASIC3 (0.49) | FEN1LRRK2FGFR3KDR | |
| SCHEMBL31024131 | 0.76 | ASIC3 (0.49) | FEN1LRRK2FGFR3KDR | |
| SCHEMBL31024037 | 0.75 | DYRK1A (0.47) | FEN1JAK3JAK1JAK2IKBKE | |
| SCHEMBL25417862 | 0.75 | DYRK1A (0.47) | FEN1JAK3JAK1JAK2IKBKE | |
| SCHEMBL14321130 | 0.73 | FEN1 (0.49) | FEN1JAK2IKBKETBK1PIK3CD | |
| SCHEMBL30063989 | 0.72 | ROCK2 (0.39) | FEN1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL15885689 | 0.71 | MET (0.45) | FEN1IKBKETBK1SYKPIK3CD | |
| SCHEMBL21425565 | 0.71 | CSF1R (0.53) | KDR | |
| SCHEMBL1663037 | 0.71 | MEN1 (0.45) | FEN1JAK2IKBKETBK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430047-A1 | PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF | Progentos Therapeutics, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023081923-A1 | PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF | Frequency Therapeutics, Inc. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081923-A1 | PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF | Frequency Therapeutics, Inc. (US) | 2023-05-11 | — | — | WO | disclosed |