Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10022385 | 0.85 | ACACB (0.56) | NOTUMSCN5ASCN10ACYP1A2SMN1; SMN2 | |
| SCHEMBL14441200 | 0.84 | MAPK1 (0.54) | NOTUMSCN5ASCN10ASMN1; SMN2NPSR1 | |
| SCHEMBL6528165 | 0.84 | NOTUM (0.69) | NOTUMSCN5ASCN10ACYP1A2SMN1; SMN2 | |
| SCHEMBL507782 | 0.83 | NOTUM (0.72) | NOTUMSCN5ASCN10ACYP1A2SMN1; SMN2 | |
| SCHEMBL201423 | 0.81 | NOTUM (0.56) | NOTUMSCN5ASCN10ACYP1A2SMN1; SMN2 | |
| SCHEMBL10904042 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2NPSR1TDP1TSHRMAPK1 | |
| SCHEMBL8245745 | 0.81 | S1PR1 (0.52) | NOTUMSCN5ASCN10ACYP1A2SMN1; SMN2 | |
| SCHEMBL8432966 | 0.79 | MAPT (0.56) | NOTUMCYP1A2SMN1; SMN2TDP1SIRT2 | |
| SCHEMBL10905724 | 0.78 | RAB9A (0.56) | NOTUMCYP1A2SMN1; SMN2TDP1TSHR | |
| SCHEMBL30566767 | 0.78 | RAB9A (0.56) | NOTUMCYP1A2SMN1; SMN2TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970470-B1 | {5-chloro-2-(2-(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)ethyl)phenyl}(phenyl)methanones as larvicidal agents | King Faisal University (SA) | 2024-04-30 | — | — | US | disclosed |
| EP-1937673-B1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI SA (FR) | 2015-10-21 | — | — | EP | disclosed |
| US-8044208-B2 | inhibit the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor); 3-(6-aminopyridin-3-yl)-2-{1-[5-(5-chlorothiophen-2-yl)isoxazol-3-ylmethyl]-1H-imidazol-4-yl}propionic acid | SANOFI-AVENTIS (FR) | 2011-10-25 | — | — | US | disclosed |
| US-20080262028-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI-AVENTIS (FR) | 2008-10-23 | — | — | US | disclosed |
| EP-1937673-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045339-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI-AVENTIS (DE) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262028-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | TFPI, TFPI2, TAF1 | NOTUM 774/4885SCN5A 2480/4885SCN10A 2365/4885 |
| US-11970470-B1 | {5-chloro-2-(2-(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)ethyl)phenyl}(phenyl)methanones as larvicidal agents | CASP3, CASP2, CASP7 | NOTUM 1319/4885SCN5A 3335/4885SCN10A 4289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.