SCHEMBL25425896

SCHEMBL25425896

COc1c(C)ccc2[nH]cc(C(=O)C(=O)Cl)c12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR4A2 P43354 8/20 0.40
▸ MAPT P10636 2/20 0.38
▸ LMNA P02545 2/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ MITF O75030 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ TUBB1 Q9H4B7 1/20 0.34
▸ CREBBP Q92793 1/20 0.34
▸ GABRP O00591 1/20 0.34
▸ GABRD O14764 1/20 0.34
▸ GABRA1 P14867 1/20 0.34
▸ GABRB1 P18505 1/20 0.34
▸ GABRG2 P18507 1/20 0.34
▸ GABRB3 P28472 1/20 0.34
▸ GABRA5 P31644 1/20 0.34
▸ GABRA3 P34903 1/20 0.34
▸ GABRA2 P47869 1/20 0.34
▸ GABRB2 P47870 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31708213 0.86 HSD17B10 (0.39) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL17417754 0.84 HSD17B10 (0.43) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL25748082 0.83 NR4A2 (0.36) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL22864639 0.82 NR4A2 (0.55) NR4A2CREBBP
SCHEMBL25423189 0.80 NR4A2 (0.34) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL25438497 0.80 ALDH1A1 (0.39) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL25289183 0.80 GABRP (0.41) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL31077662 0.80 GABRP (0.41) NR4A2MAPTLMNARAB9AMEN1
SCHEMBL25748215 0.80 PTPN1 (0.42) MAPTLMNAMEN1KMT2AGABRA1
SCHEMBL25436274 0.79 ALDH1A1 (0.38) NR4A2MAPTLMNARAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101038-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-03-27 — — US disclosed
CN-118715204-A Compounds of formula (I) 普赛洛私人有限公司 2024-09-27 — — CN disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101038-A1 COMPOUNDS NLN, SLC18A2, PYGB NR4A2 3254/4885MAPT 139/4885LMNA 2980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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