Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.36 |
| ▸ | SYK | P43405 | 7/20 | 0.36 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31428461 | 0.73 | CHRNA7 (0.50) | SYKJAK2MEN1GLAGAA | |
| SCHEMBL30163574 | 0.70 | HRH3 (0.42) | SYK | |
| SCHEMBL29695797 | 0.70 | CHRNB2 (0.54) | SYKJAK2 | |
| SCHEMBL16427563 | 0.70 | CHRNB2 (0.54) | SYKJAK2 | |
| SCHEMBL19497344 | 0.70 | ENPP2 (0.38) | TBK1SYKJAK2 | |
| SCHEMBL16292255 | 0.70 | AKR1C3 (0.49) | JAK2MEN1KMT2A | |
| SCHEMBL24680803 | 0.70 | AKR1C3 (0.49) | SYKJAK2MEN1KMT2A | |
| SCHEMBL17642662 | 0.69 | CTSS (0.40) | SYKJAK2 | |
| SCHEMBL16427245 | 0.69 | CTSS (0.38) | TBK1SYKJAK2MEN1KMT2A | |
| SCHEMBL25965585 | 0.68 | DHFR (0.44) | SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |