Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29945868 | 0.86 | GPR119 (0.48) | GPR119KDM4EPTPN2PTPN1PTPN6 | |
| SCHEMBL31056160 | 0.85 | FPR2 (0.42) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL255140 | 0.85 | NR1H2 (0.43) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL21063625 | 0.84 | USP30 (0.41) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL25308596 | 0.84 | PIK3CA (0.42) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL26090665 | 0.83 | NR1H2 (0.38) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL21063582 | 0.82 | NR1H2 (0.42) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL15293710 | 0.81 | ALDH1A1 (0.44) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL14698800 | 0.77 | USP30 (0.45) | NR1H2NAMPTUSP30RORCGPR119 | |
| SCHEMBL31052491 | 0.76 | SRC (0.48) | USP30GPR119PTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |