SCHEMBL25434291

SCHEMBL25434291

O=C(NCc1cccnc1)C1CCN(c2nc(-c3ccc(Cl)cc3)no2)CC1

nearest known ligand 0.69

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.60
▸ KMT2A Q03164 2/20 0.60
▸ MEN1 O00255 1/20 0.60
▸ L3MBTL1 Q9Y468 1/20 0.60
▸ MAPT P10636 1/20 0.56
▸ ACKR3 P25106 1/20 0.55
▸ ALDH1A1 P00352 4/20 0.53
▸ TSHR P16473 2/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ SMN1; SMN2 Q16637 2/20 0.53
▸ LMNA P02545 2/20 0.53
▸ GALR3 O60755 1/20 0.53
▸ USP2 O75604 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31546388 1.00 HTT (0.60) HTTKMT2AMEN1L3MBTL1MAPT
SCHEMBL31546349 0.92 ALDH1A1 (0.54) HTTKMT2AMEN1L3MBTL1MAPT
SCHEMBL30584903 0.92 ALDH1A1 (0.56) HTTKMT2AMEN1L3MBTL1MAPT
SCHEMBL25438262 0.89 LMNA (0.62) HTTKMT2AMEN1MAPTALDH1A1
SCHEMBL30584837 0.89 LMNA (0.62) HTTKMT2AMEN1MAPTALDH1A1
SCHEMBL31546425 0.84 LMNA (0.63) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL30584862 0.83 TSHR (0.59) KMT2AMEN1MAPTALDH1A1TSHR
SCHEMBL25432654 0.81 KMT2A (0.54) KMT2AMEN1L3MBTL1MAPTALDH1A1
SCHEMBL30584943 0.81 KMT2A (0.54) KMT2AMEN1L3MBTL1MAPTALDH1A1
SCHEMBL30584890 0.78 LMNA (0.65) KMT2AMEN1MAPTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4463452-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2024-11-20 — — EP disclosed
WO-2023177700-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2023-09-21 — — WO disclosed
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