Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31135000 | 0.68 | LOXL2 (0.36) | LOXL2LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL2187562 | 0.61 | LRRK2 (0.42) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL20092109 | 0.61 | SYK (0.48) | LOXL2LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL19805614 | 0.61 | SDHB (0.67) | — | |
| SCHEMBL1302834 | 0.61 | LOXL2 (0.50) | LOXL2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL29699125 | 0.60 | SDHB (0.34) | LRRK2 | |
| SCHEMBL18806853 | 0.58 | CYP2C9 (0.57) | LOXL2LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL29091969 | 0.58 | KDM4E (0.50) | CYP2C9CYP2C19 | |
| SCHEMBL733288 | 0.57 | LMNA (0.47) | — | |
| SCHEMBL2671981 | 0.57 | CYP2C9 (0.51) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159307-A9 | POLO-LIKE KINASE 4 (PLK4) INHIBITORS, PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF | REPARE THERAPEUTICS INC. (CA) | 2024-03-21 | — | — | WO | disclosed |
| WO-2023159307-A1 | POLO-LIKE KINASE 4 (PLK4) INHIBITORS, PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF | REPARE THERAPEUTICS INC. (CA) | 2023-08-31 | — | — | WO | disclosed |