Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TPH1 | P17752 | 1/20 | 0.47 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29262338 | 0.91 | MAPT (0.47) | ALDH1A1KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL29241233 | 0.86 | NPSR1 (0.60) | ALDH1A1MAPK1SMN1; SMN2NPSR1LGALS8 | |
| SCHEMBL25434643 | 0.86 | NPSR1 (0.60) | ALDH1A1MAPK1SMN1; SMN2NPSR1LGALS8 | |
| SCHEMBL28057569 | 0.81 | NPSR1 (0.56) | ALDH1A1KDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL30174410 | 0.79 | GABRA1 (0.41) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL30487058 | 0.79 | PTGER4 (0.34) | ALDH1A1KDM4ELMNAHTTMAPT | |
| SCHEMBL13931450 | 0.79 | NPSR1 (0.68) | ALDH1A1KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL14347066 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL24329791 | 0.78 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL30469417 | 0.78 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119585249-A | Process and intermediates for preparing 2- [ (4- {6- [ (4-cyano-2-fluorobenzyl) oxy ] pyridin-2-yl } piperidin-1-yl) methyl ] -1- [ (2S) -oxetan-2-ylmethyl ] -1H-benzimidazole-6-carboxylic acid, 1, 3-dihydroxy-2- (hydroxymethyl) propan-2-amine salt | 辉瑞公司 | 2025-03-07 | — | — | CN | claimed |
| CN-119585249-A | Process and intermediates for preparing 2- [ (4- {6- [ (4-cyano-2-fluorobenzyl) oxy ] pyridin-2-yl } piperidin-1-yl) methyl ] -1- [ (2S) -oxetan-2-ylmethyl ] -1H-benzimidazole-6-carboxylic acid, 1, 3-dihydroxy-2- (hydroxymethyl) propan-2-amine salt | 辉瑞公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-113853371-B | GLP-1R agonists and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023169436-A1 | BENZO BICYCLIC COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 广州市联瑞制药有限公司 | 2023-09-14 | — | — | WO | disclosed |