Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proguanil SCHEMBL45726 | 0.98 | LMNA (0.41) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| Proguanil SCHEMBL218859 | 0.97 | LMNA (0.40) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| Proguanil SCHEMBL9247094 | 0.92 | MEN1 (0.40) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| Proguanil SCHEMBL2539379 | 0.91 | MEN1 (0.46) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL1989233 | 0.90 | ALDH1A1 (0.44) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| Proguanil SCHEMBL2545386 | 0.88 | ALDH1A1 (0.43) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL2350583 | 0.84 | ALDH1A1 (0.49) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL11236184 | 0.84 | NPC1 (0.50) | LMNAMEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL24080891 | 0.83 | MAPT (0.47) | LMNAMEN1KMT2AALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL13584911 | 0.82 | NPC1 (0.48) | LMNAMEN1KMT2AALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263901-A1 | Process of Preparation of Proguanil | USV LTD. (IN) | 2011-10-27 | — | — | US | disclosed |
| EP-2150528-A2 | PROCESS FOR PREPARATION OF PROGUANIL HYDROCHLORIDE | USV Limited (IN) | 2010-02-10 | — | — | EP | disclosed |
| WO-2009113092-A2 | PROCESS FOR PREPARATION OF PROGUANIL HYDROCHLORIDE | USV LIMITED (IN) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263901-A1 | Process of Preparation of Proguanil | GCG, PREP, G6PD | LMNA 80/4885MEN1 1726/4885KMT2A 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.