Aloxistatin

Aloxistatin

SCHEMBL254426

CCOC(=O)[C@H]1O[C@@H]1C(=O)NC(CC(C)C)C(=O)NCCC(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CAPN1 P07384 15/20 1.00
CTSL P07711 3/20 1.00
CTSB P07858 3/20 1.00
LMNA P02545 1/20 1.00
CTSG P08311 1/20 1.00
CAPN9 O14815 3/20 0.72
MAPK1 P28482 2/20 0.72
CTSH P09668 1/20 0.49
CTSS P25774 1/20 0.49
CTSK P43235 1/20 0.49
CTSC P53634 1/20 0.49
CYP3A4 P08684 1/20 0.49
TSHR P16473 1/20 0.49
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aloxistatin SCHEMBL12620387 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL21981208 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL21981210 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL18498407 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL483320 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
SCHEMBL22273610 0.93 CAPN1 (0.87) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL9314220 0.93 CAPN1 (0.86) CAPN1CTSLCTSBLMNACTSG
SCHEMBL12653864 0.91 CAPN1 (0.83) CAPN1CTSLCTSBLMNACTSG
SCHEMBL1804811 0.91 CAPN1 (0.83) CAPN1CTSLCTSBLMNACTSG
SCHEMBL12653616 0.91 CAPN1 (0.83) CAPN1CTSLCTSBLMNACTSG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200165608-A1 INHIBITION OF VASCULAR ENDOTHELIAL CELL-MEDIATED PHAGOCYTIC PROCESSES FOR TREATMENT OF DEMYELINATING CONDITIONS NATIONAL SCIENCE FOUNDATION 2020-05-28 US claimed
US-20230233510-A1 CYSTEINE PROTEASE INHIBITORS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CORONAVIRUS ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2023-07-27 US disclosed
US-9739767-B2 Method of screening for plant defense activators, plant defense activators, and method of enhancing immune response TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) 2017-08-22 US disclosed
US-20150141252-A1 Method of Screening for Plant Defense Activators, Plant Defense Activators, and Method of Enhancing Immune Response TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) 2015-05-21 US disclosed
WO-2012029539-A1 METHOD OF SCREENING FOR PLANT DEFENSE ACTIVATORS, PLANT DEFENSE ACTIVATORS, AND METHOD OF ENHANCING IMMUNE RESPONSE TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2012-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150141252-A1 Method of Screening for Plant Defense Activators, Plant Defense Activators, and Method of Enhancing Immune Response NFATC1, TRAF6, STING1 CAPN1 3373/4885CTSL 3517/4885CTSB 2327/4885
US-20230233510-A1 CYSTEINE PROTEASE INHIBITORS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CORONAVIRUS ACE, PRSS1, CPA1 CAPN1 83/4885CTSL 28/4885CTSB 48/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.