Aloxistatin

Aloxistatin

SCHEMBL483320

CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CAPN1 P07384 15/20 1.00
CTSL P07711 3/20 1.00
CTSB P07858 3/20 1.00
LMNA P02545 1/20 1.00
CTSG P08311 1/20 1.00
CAPN9 O14815 3/20 0.72
MAPK1 P28482 2/20 0.72
CTSH P09668 1/20 0.49
CTSS P25774 1/20 0.49
CTSK P43235 1/20 0.49
CTSC P53634 1/20 0.49
CYP3A4 P08684 1/20 0.49
TSHR P16473 1/20 0.49
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aloxistatin SCHEMBL12620387 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL21981208 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL21981210 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL254426 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL18498407 1.00 CAPN1 (1.00) CAPN1CTSLCTSBLMNACTSG
SCHEMBL22273610 0.93 CAPN1 (0.87) CAPN1CTSLCTSBLMNACTSG
Aloxistatin SCHEMBL9314220 0.93 CAPN1 (0.86) CAPN1CTSLCTSBLMNACTSG
SCHEMBL12653864 0.91 CAPN1 (0.83) CAPN1CTSLCTSBLMNACTSG
SCHEMBL1804811 0.91 CAPN1 (0.83) CAPN1CTSLCTSBLMNACTSG
SCHEMBL12653616 0.91 CAPN1 (0.83) CAPN1CTSLCTSBLMNACTSG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 833 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250387462-A1 LIPID NANOPARTICLES FOR DELIVERY OF NUCLEIC ACIDS AND VACCINE FOR THE PREVENTION OF TUBERCULOSIS OR OTHER MYCOBACTERIAL INFECTIONS AKAGERA MEDICINES, INC. (US) 2025-12-25 US claimed
EP-4662491-A2 EXPEDITED NEOANTIGEN VACCINES Iogenetics, LLC. (US) 2025-12-17 EP claimed
EP-4662329-A1 CLEAVED NEOEPITOPES Iogenetics, LLC. (US) 2025-12-17 EP claimed
EP-4648769-A2 NECROSIS INHIBITOR Linkgevity Limited (GB) 2025-11-19 EP claimed
CN-120131940-A Bile duct cancer treatment medicine composition and application thereof 安徽省立医院(中国科学技术大学附属第一医院) 2025-06-13 CN claimed
US-20250152531-A1 INHIBITORS OF AUTOPHAGY AND DCAR-1 AS NOVEL ANTHELMINTIC AGENTS FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES 2025-05-15 US claimed
WO-2025096764-A1 THERAPEUTIC TARGETING OF TUMOR ESCAPE BY CAR-MEDIATED TROGOCYTOSIS UNIVERSITY OF MARYLAND, BALTIMORE (US) 2025-05-08 WO claimed
US-20250064804-A1 COMBINATION THERAPY FOR TREATING ABNORMAL CELL GROWTH RGCM SA LLC, AS PURCHASER AGENT 2025-02-27 US claimed
US-12233036-B2 Inhibitors of autophagy and DCAR-1 as novel anthelmintic agents FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (US) 2025-02-25 US claimed
US-20250043285-A1 Mammalian ATG8 Proteins and ATG9A Direct Sealing of Autophagosomal Membranes UNM RAINFOREST INNOVATIONS (US) 2025-02-06 US claimed
WO-2011017600-A2 COMPOSITIONS AND METHODS FOR TREATING BETA-AMYLOID RELATED DISEASES AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC. (ALSP INC.) (US) 2011-02-10 WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20060205671-A1 Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury EMORY UNIVERSITY 2006-09-14 US claimed
EP-1638579-A2 COMPOSITIONS AND METHODS FOR USE OF A PROTEASE INHIBITOR AND ADENOSINE FOR PREVENTING ORGAN ISCHEMIA AND REPERFUSION INJURY EMORY UNIVERSITY (US) 2006-03-29 EP claimed
WO-2005003150-A2 COMPOSITIONS AND METHODS FOR USE OF A PROTEASE INHIBITOR AND ADENOSINE FOR PREVENTING ORGAN ISCHEMIA AND REPERFUSION INJURY EMORY UNIVERSITY (US) 2005-01-13 WO claimed
CN-1548157-A SARS resisting medicine action target and its preventing and treating medicine 北京摩力克科技有限公司 2004-11-24 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250387462-A1 LIPID NANOPARTICLES FOR DELIVERY OF NUCLEIC ACIDS AND VACCINE FOR THE PREVENTION OF TUBERCULOSIS OR OTHER MYCOBACTERIAL INFECTIONS CD4, MICA, LNPK CAPN1 2446/4885CTSL 405/4885CTSB 1170/4885
US-20250043285-A1 Mammalian ATG8 Proteins and ATG9A Direct Sealing of Autophagosomal Membranes ATG7, BECN1, ATG4A CAPN1 2402/4885CTSL 2586/4885CTSB 597/4885
US-20250064804-A1 COMBINATION THERAPY FOR TREATING ABNORMAL CELL GROWTH NRAS, BRAF, BECN1 CAPN1 2596/4885CTSL 2805/4885CTSB 717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.