Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770841 | 1.00 | CTSS (0.47) | CTSSCTSKROCK2ROCK1ATM | |
| SCHEMBL10216947 | 0.89 | CTSK (0.46) | CTSSCTSKROCK2ROCK1ATM | |
| SCHEMBL10216957 | 0.89 | CTSS (0.43) | CTSSCTSKROCK2ROCK1ATM | |
| SCHEMBL1157183 | 0.86 | CTSA (0.50) | CTSSCTSK | |
| SCHEMBL25445088 | 0.86 | CTSS (0.46) | CTSSCTSKATMPTPN1CTSL | |
| SCHEMBL17841293 | 0.86 | CTSA (0.50) | CTSSCTSK | |
| SCHEMBL3447675 | 0.85 | CTSS (0.45) | CTSSCTSKATMALDH1A1TSHR | |
| SCHEMBL4663082 | 0.85 | CTSK (0.47) | CTSSCTSKATMPTPN1CTSL | |
| SCHEMBL29747547 | 0.84 | JAK2 (0.43) | CTSSCTSKATMCTSLCTSB | |
| SCHEMBL29748599 | 0.84 | JAK2 (0.43) | CTSSCTSKATMCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174662-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | CILAG AG (CH) | 2024-05-30 | — | — | US | disclosed |
| EP-4284802-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | Janssen Biotech, Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| US-20230144828-A1 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND USE THEREOF | SHANGHAI INNOFORTUNE BOITECH CO. LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| WO-2022165530-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | JANSSEN BIOTECH, INC. (US) | 2022-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240174662-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | SIK2, SIK1, SGK2 | CTSS 4076/4885CTSK 1178/4885ROCK2 338/4885 |
| US-20230144828-A1 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND USE THEREOF | GNRHR, GHRHR, LHCGR | CTSS 2411/4885CTSK 3016/4885ROCK2 3203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.