Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 11/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.56 |
| ▸ | GBA1 | P04062 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544710 | 1.00 | ADRA2C (0.71) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL29791112 | 0.96 | ADRA2A (0.76) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2549133 | 0.96 | ADRA2A (0.76) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2548228 | 0.96 | ADRA2A (0.76) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2526049 | 0.85 | ADRA2A (0.63) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2542728 | 0.84 | ADRA2C (0.60) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL29791109 | 0.84 | ADRA2A (0.60) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2545665 | 0.84 | ADRA2A (0.60) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2545666 | 0.84 | ADRA2A (0.60) | ADRA2CADRA2AADRA2BADRA1DADRA1A | |
| SCHEMBL2543113 | 0.83 | ADRA2A (0.76) | ADRA2CADRA2AADRA2BADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210338662-A1 | ALPHA-2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA | BAYER AKTIENGESELISCHAFT (DE) | 2021-11-04 | — | — | US | claimed |
| US-20110262352-A1 | ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS | ORION CORPORATION (FI) | 2011-10-27 | — | — | US | claimed |
| US-20220218700-A1 | COMBINATION OF AN ?2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA | BAYER AKTIENGESELLSCHAFT (DE) | 2022-07-14 | — | — | US | disclosed |
| US-20210338662-A1 | ALPHA-2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA | BAYER AKTIENGESELISCHAFT (DE) | 2021-11-04 | — | — | US | disclosed |
| US-20110262352-A1 | ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS | ORION CORPORATION (FI) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338662-A1 | ALPHA-2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA | ADRA2C, ADRB2, ADRA2A | ADRA2C 1/4885ADRA2A 3/4885ADRA2B 4/4885 |
| US-20220218700-A1 | COMBINATION OF AN ?2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA | ADRA2C, ADRB2, ADRA1D | ADRA2C 1/4885ADRA2A 9/4885ADRA2B 8/4885 |
| US-20110262352-A1 | ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS | ADRA2C, ADRA2A, HTR2C | ADRA2C 1/4885ADRA2A 2/4885ADRA2B 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.