SCHEMBL25447154

SCHEMBL25447154

O=C(NCCc1cccc(F)c1)c1cc(Cl)nnc1Sc1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.52
ABCB1 P08183 1/20 0.48
TP53 P04637 1/20 0.43
CA2 P00918 1/20 0.43
CA4 P22748 1/20 0.43
SNCA P37840 5/20 0.42
LMNA P02545 2/20 0.42
THRB P10828 2/20 0.42
POLB P06746 1/20 0.42
ALDH1A1 P00352 2/20 0.42
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ABL1 P00519 1/20 0.40
SRC P12931 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25447231 0.93 CA2 (0.50) CNR1ABCB1TP53CA2CA4
SCHEMBL25447260 0.91 ALDH1A1 (0.50) CNR1ABCB1TP53CA2CA4
SCHEMBL25447207 0.89 TDP1 (0.53) CNR1TP53CA2CA4LMNA
SCHEMBL25447186 0.88 SMN1; SMN2 (0.53) CNR1TP53CA2CA4LMNA
SCHEMBL25447285 0.87 MAPT (0.50) TP53CA2CA4LMNAPOLB
SCHEMBL25447314 0.85 CNR1 (0.54) CNR1TP53CA2LMNAALDH1A1
SCHEMBL25446937 0.85 CNR1 (0.56) CNR1ABCB1TP53CA2CA4
SCHEMBL25447261 0.84 MAPT (0.56) TP53CA2CA4LMNAMAPT
SCHEMBL25447454 0.83 CA2 (0.59) TP53CA2CA4LMNAPOLB
SCHEMBL25447366 0.82 CA2 (0.52) CNR1TP53CA2CA4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023078915-A1 BIS(HETERO)ARYL THIOETHER (THIO)AMIDES AS FUNGICIDAL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2023-05-11 WO disclosed