Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 6/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927109 | 0.92 | PTAFR (0.46) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927153 | 0.90 | GABRA1 (0.46) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL30201836 | 0.90 | GABRA1 (0.46) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927176 | 0.88 | PTAFR (0.43) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL25448187 | 0.86 | GABRA1 (0.36) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927143 | 0.86 | PTAFR (0.50) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL25448183 | 0.85 | P2RX7 (0.35) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL25448184 | 0.84 | ADORA2A (0.33) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL30201991 | 0.77 | P2RX7 (0.35) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL23927183 | 0.77 | PTAFR (0.50) | PTAFRGABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230141603-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230141603-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRB1, GABRB3 | PTAFR 1947/4885GABRA1 1/4885GABRA5 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.