Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2743 | 0.99 | L3MBTL1 (0.49) | L3MBTL1CD274ESR2MYCWDR5 | |
| SCHEMBL2083 | 0.92 | SCN8A (0.46) | L3MBTL1CD274ESR2MYCWDR5 | |
| SCHEMBL8383188 | 0.90 | MYC (0.43) | L3MBTL1CD274ESR2MYCWDR5 | |
| SCHEMBL6606339 | 0.85 | ESR2 (0.49) | CD274ESR2MYCWDR5PDCD1 | |
| SCHEMBL2739 | 0.83 | FFAR1 (0.46) | CD274ESR2MYCWDR5FFAR1 | |
| SCHEMBL6606543 | 0.82 | HRH4 (0.54) | CD274ESR2MYCWDR5PDCD1 | |
| SCHEMBL6957193 | 0.81 | ESR2 (0.51) | ESR2MYCWDR5FFAR1AKR1B1 | |
| SCHEMBL2405 | 0.80 | DRD4 (0.50) | ESR2FFAR1AKR1B1KDM4EMEN1 | |
| SCHEMBL2401 | 0.80 | ESR2 (0.50) | CD274ESR2MYCWDR5PDCD1 | |
| SCHEMBL7435402 | 0.79 | ESR2 (0.56) | ESR2MYCWDR5FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |