Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2401 | 0.83 | ESR2 (0.50) | FFAR1AKR1B1MAPK1MAOAMEN1 | |
| SCHEMBL2083 | 0.82 | SCN8A (0.46) | FFAR1AKR1B1KDM4ESCN8AMEN1 | |
| SCHEMBL2694 | 0.82 | ESR2 (0.49) | FFAR1AKR1B1MAOAMEN1CYP1A2 | |
| SCHEMBL2958 | 0.82 | GBA1 (0.48) | DRD4FFAR1AKR1B1BCHEMAPK1 | |
| SCHEMBL6606543 | 0.81 | HRH4 (0.54) | MAPK1SCN8AMAOAMEN1USP2 | |
| SCHEMBL2545 | 0.80 | L3MBTL1 (0.47) | FFAR1AKR1B1MAPK1KDM4ESCN8A | |
| SCHEMBL2739 | 0.79 | FFAR1 (0.46) | DRD4FFAR1AKR1B1BCHEMAPK1 | |
| Hydrochloric Acid SCHEMBL2743 | 0.79 | L3MBTL1 (0.49) | FFAR1AKR1B1MAPK1KDM4ESCN8A | |
| SCHEMBL6606339 | 0.78 | ESR2 (0.49) | FFAR1AKR1B1MAPK1KDM4EMEN1 | |
| SCHEMBL8383188 | 0.78 | MYC (0.43) | DRD4FFAR1AKR1B1MAPK1SCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |