Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545 | 0.92 | L3MBTL1 (0.47) | SCN8AMYCWDR5ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL2743 | 0.91 | L3MBTL1 (0.49) | SCN8AMYCWDR5ESR2KDM4E | |
| SCHEMBL6606543 | 0.85 | HRH4 (0.54) | SCN8AMYCWDR5ESR2CD274 | |
| SCHEMBL8383188 | 0.85 | MYC (0.43) | SCN8AMYCWDR5ESR2L3MBTL1 | |
| SCHEMBL2958 | 0.84 | GBA1 (0.48) | SCN8AESR2KDM4EFFAR1AKR1B1 | |
| SCHEMBL2401 | 0.83 | ESR2 (0.50) | MYCWDR5ESR2CD274PDCD1 | |
| SCHEMBL2405 | 0.82 | DRD4 (0.50) | SCN8AESR2KDM4EFFAR1AKR1B1 | |
| SCHEMBL6960974 | 0.82 | FFAR1 (0.49) | MYCWDR5ESR2FFAR1AKR1B1 | |
| SCHEMBL6606339 | 0.82 | ESR2 (0.49) | MYCWDR5ESR2KDM4ECD274 | |
| SCHEMBL2694 | 0.82 | ESR2 (0.49) | MYCWDR5ESR2CD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |