Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 5/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 5/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25480249 | 0.90 | HRH3 (0.56) | HRH3CYP2D6KCNH2HSD11B1ALDH1A1 | |
| SCHEMBL25480250 | 0.90 | HRH3 (0.56) | HRH3CYP2D6KCNH2HSD11B1ALDH1A1 | |
| SCHEMBL26295608 | 0.87 | HRH3 (0.47) | HRH3CYP2D6KCNH2CHRNB2CHRNA3 | |
| SCHEMBL26494224 | 0.86 | HRH3 (0.55) | HRH3CYP2D6KCNH2CHRNB2CHRNA3 | |
| SCHEMBL26295616 | 0.86 | HRH3 (0.49) | HRH3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL10119970 | 0.85 | CHRNB2 (0.50) | HRH3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL26790076 | 0.84 | HTT (0.46) | HRH3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL25480245 | 0.84 | HRH3 (0.44) | HRH3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL26170649 | 0.82 | HRH3 (0.55) | HRH3CYP2D6KCNH2CHRNB2CHRNA3 | |
| SCHEMBL14453913 | 0.82 | HRH3 (0.66) | HRH3CYP2D6KCNH2HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2024-01-25 | — | — | US | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| US-20230158151-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING TARGET PROTEINS, COMPOSITIONS, COMPRISING THE SAME, METHODS OF THEIR MAKING, AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | HRH3 3347/4885CYP2D6 3436/4885KCNH2 4316/4885 |
| US-20230158151-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING TARGET PROTEINS, COMPOSITIONS, COMPRISING THE SAME, METHODS OF THEIR MAKING, AND METHODS OF THEIR USE | MDM2, XIAP, ADRM1 | HRH3 3926/4885CYP2D6 3652/4885KCNH2 4882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.