Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 9/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551827 | 0.89 | AKR1B1 (0.33) | AKR1B1BACE1BACE2 | |
| SCHEMBL444596 | 0.74 | CASP6 (0.39) | AKR1B1 | |
| SCHEMBL449885 | 0.72 | BACE1 (0.38) | AKR1B1BACE1 | |
| SCHEMBL446093 | 0.71 | AKR1B1 (0.55) | AKR1B1 | |
| SCHEMBL448218 | 0.70 | BACE1 (0.44) | BACE1BACE2 | |
| SCHEMBL429148 | 0.61 | HTT (0.40) | AKR1B1 | |
| SCHEMBL28935880 | 0.61 | DRD2 (0.43) | XIAPBIRC2 | |
| SCHEMBL17586445 | 0.60 | AVPR1A (0.51) | — | |
| SCHEMBL5372273 | 0.60 | CA9 (0.46) | — | |
| SCHEMBL17806128 | 0.60 | PGR (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |