Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23840409 | 0.92 | MALT1 (0.42) | NPC1RAB9ASMN1; SMN2PIK3C3MALT1 | |
| SCHEMBL23840445 | 0.92 | PIK3C3 (0.38) | NPC1RAB9APIK3C3MALT1KMT2A | |
| SCHEMBL23840365 | 0.89 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2PIK3C3MALT1 | |
| SCHEMBL23840355 | 0.88 | MALT1 (0.47) | PIK3C3MALT1BRAF | |
| SCHEMBL23840564 | 0.88 | PIK3C3 (0.38) | NPC1RAB9APIK3C3MALT1KMT2A | |
| SCHEMBL25485494 | 0.86 | KCNK3 (0.52) | NPC1RAB9ASMN1; SMN2KMT2AKCNK3 | |
| SCHEMBL23840341 | 0.85 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2PIK3C3KMT2A | |
| SCHEMBL23840544 | 0.85 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2PIK3C3PKM | |
| SCHEMBL23840465 | 0.84 | NAMPT (0.49) | NPC1RAB9ASMN1; SMN2PIK3C3KMT2A | |
| SCHEMBL23840623 | 0.83 | KMT2A (0.44) | SMN1; SMN2PIK3C3KMT2AKCNK3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159509-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159509-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, PPM1D | NPC1 1886/4885RAB9A 455/4885SMN1; SMN2 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.