Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14944044 | 0.75 | TDP1 (0.46) | TDP1SMARCA2SMARCA4PBRM1KDM4E | |
| SCHEMBL20829977 | 0.68 | ACVR2A (0.33) | TRIM58ALDH1A1 | |
| SCHEMBL11888348 | 0.68 | RAB9A (0.43) | TDP1SMARCA2SMARCA4PBRM1KDM4E | |
| SCHEMBL25711816 | 0.67 | NCF1 (0.43) | TDP1TRIM58KDM4EALDH1A1GAA | |
| SCHEMBL23205340 | 0.65 | RAB9A (0.52) | TDP1SMARCA2SMARCA4PBRM1KDM4E | |
| SCHEMBL21537838 | 0.65 | MKNK2 (0.40) | TDP1TRIM58KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1752808 | 0.65 | ACHE (0.51) | TDP1SMARCA2SMARCA4PBRM1KDM4E | |
| SCHEMBL1752972 | 0.63 | ACHE (0.50) | TDP1SMARCA2SMARCA4PBRM1KDM4E | |
| SCHEMBL1752857 | 0.63 | ACHE (0.68) | TDP1ACHELMNACYP1A2CYP3A4 | |
| SCHEMBL21284326 | 0.62 | KDM4E (0.36) | TRIM58KDM4EALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230149549-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149549-A1 | SMARCA DEGRADERS AND USES THEREOF | SMARCA1, SMARCB1, SMARCE1 | TDP1 1914/4885TRIM58 281/4885SMARCA2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.