Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487680 | 0.80 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL21284326 | 0.73 | KDM4E (0.36) | ACVR2ATGFBR1ALDH1A1TRIM58 | |
| SCHEMBL14012369 | 0.72 | — | — | |
| SCHEMBL872385 | 0.70 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL18869729 | 0.70 | POLB (0.32) | — | |
| SCHEMBL25487682 | 0.68 | TDP1 (0.42) | ALDH1A1TRIM58 | |
| SCHEMBL28954619 | 0.68 | — | — | |
| SCHEMBL7640865 | 0.67 | CALM1 (0.37) | ALDH1A1 | |
| SCHEMBL21939041 | 0.67 | APLNR (0.31) | — | |
| SCHEMBL19477494 | 0.67 | ALDH1A1 (0.38) | ACVR2ATGFBR1ALDH1A1TRIM58 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190083482-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190083482-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | ACVR2A 4270/4885TGFBR1 2484/4885ALDH1A1 2460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.