Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548909 | 0.82 | ALDH1A1 (0.48) | MAPTALDH1A1HPGDATMSMN1; SMN2 | |
| SCHEMBL2543859 | 0.82 | POLB (0.42) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL5559263 | 0.76 | MAPT (0.39) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL9643966 | 0.73 | MAPT (0.38) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL975710 | 0.73 | MAPT (0.60) | MAPTPOLBALDH1A1HPGDTSHR | |
| SCHEMBL5546372 | 0.72 | CCNA2 (0.45) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL13451548 | 0.72 | NR1H4 (0.38) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL6137459 | 0.71 | MAPT (0.40) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL9643819 | 0.71 | MAPT (0.40) | AGTR1AGTR2MAPTPOLBALDH1A1 | |
| SCHEMBL1778181 | 0.71 | ALDH1A1 (0.55) | MAPTPOLBALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| EP-2358698-B1 | TETRASUBSTITUTED PYRIDAZINE AS HEDGEHOG PATHWAY ANTAGONISTS | LILLY CO ELI (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2358698-B1 | TETRASUBSTITUTED PYRIDAZINE AS HEDGEHOG PATHWAY ANTAGONISTS | LILLY CO ELI (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| WO-2010056588-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | SHH, SMO, GLI1 | AGTR1 1519/4885AGTR2 1987/4885MAPT 4803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.