Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545955 | 0.99 | GPR119 (0.40) | GPR119HRH2HRH1JAK2JAK1 | |
| SCHEMBL2574957 | 0.86 | HRH1 (0.35) | HRH2HRH1 | |
| SCHEMBL28675906 | 0.71 | KEAP1 (0.47) | GPR119JAK2JAK1ACKR3EPHX2 | |
| SCHEMBL8253901 | 0.70 | USP2 (0.51) | ACKR3TLR8EPHX2KMT5A | |
| Pyrazine SCHEMBL28467340 | 0.70 | TLR8 (0.51) | GPR119HRH2HRH1ACKR3TLR8 | |
| SCHEMBL1714805 | 0.69 | HRH2 (0.68) | GPR119HRH2HRH1EPHX2 | |
| SCHEMBL4832556 | 0.69 | GPR119 (0.57) | GPR119ACKR3POLB | |
| SCHEMBL3664650 | 0.68 | NEK2 (0.33) | — | |
| SCHEMBL8207909 | 0.68 | LTA4H (0.36) | — | |
| SCHEMBL27148828 | 0.67 | GPR119 (0.58) | GPR119HRH2HRH1ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121055-A1 | PYRIDINYL DERIVATIVES COMPRISING A CYANOGUANIDINE OR SQUARIC ACID MOIETY | TOPOTARGET A/S (DK) | 2011-10-06 | — | — | WO | claimed |