Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2552266 | 0.97 | SIGMAR1 (0.41) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| SCHEMBL12266826 | 0.97 | SIGMAR1 (0.41) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| SCHEMBL2552264 | 0.97 | SIGMAR1 (0.41) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| Hydrochloric Acid SCHEMBL2551936 | 0.94 | SIGMAR1 (0.42) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| Hydrochloric Acid SCHEMBL3290040 | 0.94 | SIGMAR1 (0.44) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| Hydrochloric Acid SCHEMBL1539025 | 0.94 | SIGMAR1 (0.44) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| SCHEMBL808900 | 0.91 | SIGMAR1 (0.46) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| Hydrochloric Acid SCHEMBL1049917 | 0.91 | GRIN2D (0.40) | SIGMAR1KDM4EGRIN2DGRIN3BGRIN1 | |
| SCHEMBL2229008 | 0.91 | SIGMAR1 (0.46) | SIGMAR1ESR1ESR2KDM4EGRIN2D | |
| Hydrochloric Acid SCHEMBL1685878 | 0.91 | GRIN2D (0.40) | SIGMAR1KDM4EGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9175104-B2 | Ethylene polymerization process and polyolefin | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-11-03 | — | — | US | disclosed |
| US-8916664-B2 | Olefin polymerization process | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-12-23 | — | — | US | disclosed |
| EP-2552973-A1 | IMPROVED OLEFIN POLYMERIZATION PROCESS | E.I. Du Pont De Nemours And Company (US) | 2013-02-06 | — | — | EP | disclosed |
| EP-2552972-A1 | IMPROVED ETHYLENE POLYMERIZATION PROCESS AND POLYOLEFIN | E.I. Du Pont De Nemours And Company (US) | 2013-02-06 | — | — | EP | disclosed |
| US-20120309915-A1 | ETHYLENE POLYMERIZATION PROCESS AND POLYOLEFIN | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120309916-A1 | OLEFIN POLYMERIZATION PROCESS | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-06 | — | — | US | disclosed |
| WO-2011126787-A1 | IMPROVED OLEFIN POLYMERIZATION PROCESS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011126784-A1 | IMPROVED ETHYLENE POLYMERIZATION PROCESS AND POLYOLEFIN | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-10-13 | — | — | WO | disclosed |