Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 3/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25526353 | 0.81 | GRM2 (0.43) | GRM2MAPK13MAPK14 | |
| SCHEMBL25521381 | 0.78 | GRM2 (0.40) | GRM2LRRK2MAPK13TNK2NOS3 | |
| SCHEMBL25523929 | 0.78 | GRM2 (0.40) | GRM2LRRK2MAPK13TNK2NOS3 | |
| SCHEMBL25533147 | 0.78 | GRM2 (0.38) | GRM2BTKMAPK13 | |
| SCHEMBL30397943 | 0.77 | MAPK13 (0.41) | GRM2BTKMAPK13 | |
| SCHEMBL30397669 | 0.77 | MAPK13 (0.41) | GRM2BTKMAPK13 | |
| SCHEMBL30397855 | 0.77 | MAPK14 (0.42) | GRM2PIM1MAPK14 | |
| SCHEMBL25532532 | 0.77 | MAPK14 (0.42) | GRM2PIM1MAPK14 | |
| SCHEMBL25516112 | 0.77 | MAPK14 (0.42) | GRM2PIM1MAPK14 | |
| Trifluoroacetic Acid SCHEMBL25420616 | 0.75 | CCR5 (0.41) | GRM2BTKMAPK13PIM1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |