Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25533147 | 0.85 | GRM2 (0.38) | GRM2MAPK13 | |
| SCHEMBL25526353 | 0.81 | GRM2 (0.43) | GRM2MAPK13 | |
| SCHEMBL30397943 | 0.80 | MAPK13 (0.41) | GRM2MAPK13ADORA2A | |
| SCHEMBL30397669 | 0.80 | MAPK13 (0.41) | GRM2MAPK13ADORA2A | |
| SCHEMBL25522679 | 0.78 | GRM2 (0.40) | GRM2MAPK13LRRK2TNK2NOS3 | |
| SCHEMBL25521381 | 0.78 | GRM2 (0.40) | GRM2MAPK13LRRK2TNK2NOS3 | |
| SCHEMBL30397855 | 0.77 | MAPK14 (0.42) | GRM2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL25516112 | 0.77 | MAPK14 (0.42) | GRM2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL25532532 | 0.77 | MAPK14 (0.42) | GRM2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30397394 | 0.76 | GRM2 (0.37) | GRM2MAPK13ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |