Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | RECQL | P46063 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25219229 | 0.86 | CYP1A2 (0.83) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL6847172 | 0.84 | CYP1A2 (0.71) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL460340 | 0.84 | CYP1A2 (0.75) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL27582896 | 0.83 | CYP1A2 (1.00) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL6847258 | 0.83 | CYP2C19 (0.68) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL27600244 | 0.82 | RECQL (0.91) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL11601049 | 0.82 | CYP1A2 (0.63) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL15749696 | 0.82 | CYP1A2 (0.63) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL25522734 | 0.82 | ALDH1A1 (0.70) | CYP1A2CYP2C19RECQLHTTCYP3A4 | |
| SCHEMBL17786274 | 0.82 | CYP1A2 (0.68) | CYP1A2CYP2C19RECQLHTTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | CYP1A2 4629/4885CYP2C19 3887/4885RECQL 3187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.