Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 8/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25522223 | 0.85 | SCN8A (0.39) | ADORA2AMAOAMAOBHTR1ADYRK1B | |
| SCHEMBL31064643 | 0.83 | KDM1A (0.39) | KDM1AMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL31064603 | 0.81 | KDM1A (0.51) | ADORA2AKDM1AMAOAMAOBDYRK3 | |
| SCHEMBL23758036 | 0.81 | NPC1 (0.48) | KDM1AMAOAMAOBF2KDM4E | |
| SCHEMBL30025826 | 0.81 | NPC1 (0.48) | KDM1AMAOAMAOBF2KDM4E | |
| SCHEMBL25207059 | 0.81 | HTR1A (0.38) | ADORA2AKDM1AMAOAMAOBHTR1A | |
| SCHEMBL23757857 | 0.80 | KDM1A (0.37) | ADORA2AKDM1AMAOAMAOBF2 | |
| SCHEMBL25522228 | 0.79 | TLR7 (0.41) | ADORA2AHTR1AKDM4ENPC1RAB9A | |
| SCHEMBL25225376 | 0.78 | ALDH1A1 (0.43) | ADORA2AKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL25523353 | 0.77 | CXCR4 (0.41) | ADORA2AHTR1AKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | ADORA2A 4422/4885KDM1A 41/4885MAOA 4214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.