Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 6/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740398 | 0.74 | NPC1 (1.00) | LMNATSHRHTTNPC1TP53 | |
| SCHEMBL18482772 | 0.66 | NOTUM (0.53) | TSHRNPC1RAB9AL3MBTL1GAA | |
| SCHEMBL15903980 | 0.65 | KDM4E (0.47) | LMNATSHRHTTNPC1RAB9A | |
| SCHEMBL28369258 | 0.64 | L3MBTL1 (0.54) | LMNATSHRHTTNPC1TP53 | |
| SCHEMBL29428404 | 0.64 | L3MBTL1 (0.54) | LMNATSHRHTTNPC1TP53 | |
| SCHEMBL21225466 | 0.62 | ALDH1A1 (0.61) | LMNAHTTL3MBTL1TDP1GAA | |
| SCHEMBL21165173 | 0.60 | NOTUM (0.47) | LMNATSHRHTTNPC1TP53 | |
| SCHEMBL6417366 | 0.60 | MEN1 (1.00) | LMNATP53L3MBTL1TDP1GAA | |
| SCHEMBL105281 | 0.59 | MAPT (0.51) | TP53RAB9AL3MBTL1TDP1GAA | |
| SCHEMBL18483232 | 0.59 | NOTUM (0.59) | TSHRNPC1RAB9AL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011127333-A2 | COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2011-10-13 | — | — | WO | disclosed |